The Italian-American Mob (La Cosa Nostra) has never actually made Los Santos it's home, it comes and goes. Several individuals have tried to make a mark in the city but have never stuck to it, most of them eventually get incarcerated or end up heading back to the big apple. The Morra Crime Family seemed to have broken the curse for a moment making a mark in a city infested with gang bangers and cartel operatives but the disappearance of  prominent figureheads caused there to be a halt in what wa